According to a study published in the journal Nature Aging
Two major waves of age-related changes can be observed at ages 44 and 60 years.
The researchers followed 108 volunteers, and took different samples from them regularly. A total of 135,000 different molecules and microbes were examined, including RNA, proteins, and metabolites, as well as gut and skin bacteria, viruses, and fungi.
Professor Michael Snyder, director of the Center for Genomics and Personalized Medicine at Stanford University and lead author of the study, said of the findings:
We don't change gradually over time. These are really dramatic changes.
The researchers were surprised when they found that The aging wave is observed in the mid-forties in both women and men.“This suggests that while menopause or perimenopause may contribute to the changes seen in women in their mid-40s, other, more important factors are likely to influence these changes in both men and women,” explained study co-author Dr. Xiaotao Chen.
- During the first wave of change Molecules linked to cardiovascular disease are altered, as is the ability to metabolize caffeine, alcohol and fat.
- A The second wave It affects molecules involved in immune system regulation, carbohydrate metabolism and kidney function.
- Molecular changes associated with skin and muscle aging were observed at both periods.
The research results are consistent with previous observations that were certain. The risk of age-related diseases does not increase gradually, but in leaps and bounds.
For example, the risk of Alzheimer's disease and cardiovascular disease increases sharply after age 60.
According to the study authors, the findings could contribute to the development of targeted interventions. Professor Snyder stressed:
I am a strong believer in trying to make lifestyle changes while we are still healthy.
Cover image is an illustration. Cover image source: Getty Images
