Norbert Pardi and his team can penetrate the development of RNA vaccines developed by Katalin Karikó, a Nobel Prize -winning scientist, who previously worked with the Nobel Prize for Physiology and Medicine. Before publishing it in the spring, a professor at the University of Pennsylvania detailed the importance of their discovery in an exclusive interview with Kossuth Radio.
Catalin Carico and scientists from Kisagszils recently held a general meeting. About their last discovery at this time only a Radio KosouthNorbert Bardi, a professor at the University of Pennsylvania. Biochemistry worked with Catalin Catalin to develop the Messenger RNA technology, but now leads an independent research laboratory. Their results are so new that it will only be published in the spring in the famous nature nanotechnology. The essence of their discovery is that the Messenger RNA vaccines for various diseases not only deserve the design of RNA, but also fat molecules that contain RNA, which contain the information needed to combat nurses or cancer.
“RNA is a large molecule, negatively charged, so it cannot pass through the cell membrane to practice its effect, in very small quantities, so it takes a kind of mechanism to reach it. The fat molecule helps him. Recent discoveries have also shown that this fat molecule is this Very good immune tanning, which is especially important for vaccines. ”The researcher began to explain the reason for the importance of these fat molecules in vaccines.
the Radio Kosouth Explorer – about the world of science In its presentation, he also made it clear that the quality of the immune response is important to the effectiveness of the vaccine. Viruses are more desirable and effective for antibodies, while bacteria or cancer cells are a cellular immune response.
“In this post that will be published soon, our discovery is that we can show examples of fat molecules surrounding the RNA molecules, and how we can change its composition, according to He said, with emphasizing that these fat molecules have been discovered for a long time, but they can change the percentage of their disease they want to overcome, that is, antibodies or the predominance of cellular immune response. For example, the latter is the advantage of the influenza vaccine and the last against tuberculosis. In their next post, they describe that they are working in mouse fortification experiments, whether infectious diseases or in the case of vaccination from cancer. Later, they will look at how this works in larger animal models, such as monkeys, then tested on humans. “If it becomes clear that our discoveries in the mouse can be planted somewhat in a large animal model or a human, then this will be an important discovery. After all, we can say that if we develop a cancer vaccine, you must choose a composition that is primarily a immune response to the cells Toy In the direction of the antibody. I think we will have the results of the next year. Norbert Bardi revealed.
The full conversation can be called on the exhibition's media click page.
Explorer-About the World of Science-SCIENCE-2: 30 pm on Thursday on Kossuth Radio.
